1. DENOSYL
Factor: S-adenosylmethionine (SAMA)
American Nutrima Nutramax
Dosage: 20mg/kg/d
1. Efficiency
1.1 Transmethylation efficiency: intervening phospholipids Synthesis is particularly important for cell membrane structure, stability and function.
1.2 Transsulfation efficiency: It is the precursor of glutathione and synthesizes glutathione. Glutathione is a powerful antioxidant that is involved in many metabolisms of the body and liver detoxification. Glutathione is an important liver detoxifier that helps protect liver cells. When the liver is damaged, the production of endogenous glutathione is reduced, thereby affecting liver function.
1.3 Transaminopropyl function: Aminopropyl plays a key role in the production of anti-inflammatory substances, the production of protein and DNA, promoting cell replication, and liver tissue transformation.
1.4SAMe has anti-inflammatory, pain-reducing and tissue-repairing effects. It has obvious effects on arthritis. It can significantly promote cartilage production and reduce joint pain, hardness and swelling. SAMe has been used as a prescription drug to treat arthritis in Europe.
2. Usage
This product is an enteric-coated film-coated tablet. It must be taken completely on an empty stomach, 1 tablet each day and night, 1 hour before eating. Take it about 4 hours after eating. Do not break it, break it, chew it or melt it.
In order to prevent food refusal when feeding medicine, you can wrap it in a small amount of soft food and take it; if you take it with food, please take it at twice the dosage. The number of tablets at any time can be gradually reduced or reduced according to the needs of the pet. Many pets should take DenosylTM at a long-term maintenance dose, which is 1/3 of the normal dosage.
It is currently the first drug used by American veterinarians to treat liver diseases in various dogs and cats. Its main functions are to repair damaged liver cells, eliminate ascites, restore normal bile function, reduce jaundice, and promote liver disease in dogs and cats. Automatic feeding. Can produce obvious results in a short period of time.
2. Denamarin Liver Protecting and Consolidating Tablets 90 and Liver Protecting and Consolidating Tablets 225mg Chewable Tablets
Ingredients: s-adenosylmethionine, silymarin
American Nutramax
1 Efficiency
1.1 Liver protection efficiency: It has strong antioxidant effect , protect liver cells from immunityIt is damaged by free radicals and captures free radicals, which is far more effective than vitamin E and enhances the detoxification function of the liver.
1.2 Prevent liver cirrhosis and hepatitis, promote bile flow, promote digestion and absorb intestinal nutrients.
1.3 Promote protein synthesis, accelerate the creation of new liver cells, or allow damaged liver cells to repair themselves, and increase glutathione levels. Therefore, it is called "natural liver protection medicine".
1.4 Anti-tumor effect: Various reactive oxygen species can oxidize guanine to produce 8-hydroxyguanine, causing DNA damage and thereby causing tumors. The use of antioxidants, especially free radical scavengers, can prevent this process. of the outbreak.
2. Usage
2.1 Take on an empty stomach (at least 1 hour before meals and 4 hours after meals).
2.2 Liver Protecting and Consolidating Tablets 90mg: sugar-coated tablets to protect them from gastric acid damage. Do not break it, as it will affect intestinal absorption. If feeding is difficult, you can wrap it with some food, but try to avoid it or increase the amount appropriately.
2.3 Liver protection tablets 225mg chewable tablets: can be separated and not easily oxidized through encapsulation technology. It is not recommended to get involved in water or syrup.
2.4 The added ingredient silymarin may cause gastrointestinal reactions (vomiting or diarrhea).
3. Zentonil
Ingredients: S-adenosylmethionine, lecithin
Veillon, France (Zentonil)
1. Efficacy
Lecithin is known as the "third nutrient" alongside protein and vitamins. Nourishes the heart muscle, regulates serum lipid levels, lowers cholesterol levels, and protects the liver.
2. Usage
Because the important ingredient is also S-adenosylmethionine, it must be taken on an empty stomach. However, it is processed using microencapsulation technology to prevent biochemical reactions, enteric coating, good taste, and can be separated, crushed or chewed.
4. Fonzgan HEPAPHIRST
1. Factors and efficiency
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Comparison of Medication Understandings for Liver Diseases in Dogs and Cats
2. Usage
Recommended dosage: one tablet per 5 kilograms per day during the health care period. 2-3 times the dose can be adjusted according to the situation.
Suitable for: elevated liver index, acute or chronic conditions. Liver health care during long-term drug treatment of liver damage, chronic diseases such as hepatitis, poisoning, fatty liver, etc.
Note: Conventional hepatoprotective drugs containing SAMe ingredients may contain less silymarin (silymarin may not be used in cases of liver disease). The amount of auxiliary adjustment is 20-50mg/kg/d) Fonzigan can provide vitamin B complex (SAMe changes into glutathione) and a higher dose of silymarin. Fonzigan can help Danoxi and protect the liver. Consolidated tablets or Entunil are more effective.
5. Hepatoxin
Ingredients: taurine, L-carnitine, vitamin E, coenzyme. Q10, essential fatty acids (DHA and EPA)
Korea
1. Efficiency
1.1 Taurine: Cat An essential amino acid. Taurine can combine with bile acids to produce taurocholic acid, which is essential for the absorption of lipids in the digestive tract, eliminates bile blockage, reduces bile flow, etc., and also protects muscle strength and freedom. It is a base and antioxidant. It can improve myocardial insufficiency, accelerate myocardial weakness and protect normal retinal function.
1.2 L-carnitine: It is an essential amino acid for protecting normal nutrition and fat metabolism. It is an essential amino acid for myocardium, liver and nerves. It can enhance myocardial energy, improve myocardial breaking ability, and protect the normal function of the heart. It enhances lipid metabolism and regulates the function of fatty liver.
1.3 Vitamin E: Antioxidant, inhibits myocardial damage caused by free radicals. Accelerate myocardial weakness
1.4 Coenzyme Q10: Improve myocardial function, lower cholesterol, lower blood pressure
2. Regulation
2.1 Heart aspect: Improve animals' cardiac interrupting ability, regulate dilated heart disease, improve cardiac insufficiency, protect blood vessels, and prevent thrombosis
2.2 Liver aspect: mainly target fatty liver, bile deposition, and promote bile. Penetration, thereby improving liver function. It is less effective in other types of liver diseases
2.3 Other aspects: lower cholesterol, enhance immunity, and strengthen muscles.
3. Dosage: Take 1 tablet twice a day for those weighing less than 10kg. Take 2 tablets twice a day for those weighing more than 10kg.The effect of synergistic fatty acids is better.
6. Hepatic Tylo Glucuronolactone
1. Efficiency
Pharmacological efficiency : After this product is added to the body, it can combine with poisons containing hydroxyl or carboxyl groups to form low-toxic or non-toxic compounds that are eliminated in the urine and have liver protection and detoxification effects. In addition, glucuronic acid can reduce liver glycogen content and reduce fat reserves.
After this drug is added to the body, the lactone ring is opened under the catalysis of enzymes and converted into glucuronic acid to exert its effect. The latter is one of the key detoxification substances in the body. In addition, under the action of glucuronide-changing enzyme, it can combine with metabolites, poisons or drugs containing phenolic groups, hydroxyl groups, carboxyl groups and amino groups in the liver or intestines to produce non-toxic glucuronic acid complexes that are eliminated in the urine. in vitro. However, cats lack the enzyme glucuronidase.
2. Note:
It is basically ineffective for cats to use Heptalyx, but it will increase the metabolic burden on the liver.
It can be used in dogs for the auxiliary treatment of acute and chronic hepatitis in dogs, toxic hepatitis due to food or drugs, and hepatoprotective and toxic treatment.
3. Dosage: Dog 50-200mg/time, taken orally, 2-3 times a day.
100-200mg/time, intramuscular injection or intravenous infusion, once a day.
7. Liver-protecting capsules
1. Factors: Bupleurum, Cyperus rotunda, Turmeric, Angelica sinensis, Atractylodes, Schisandra chinensis, astragalus, white peony root, poria, capillaris, isatis root, licorice, etc.
2. Efficacy: Soothes the liver and regulates qi, clears away heat and dissipates stagnation, softens the liver and strengthens the spleen, regulates qi and blood, reduces transaminases, and is used for acute hepatitis and early hepatitis.
3. Dosage: 1 capsule per 10kg, 2 times a day, one month as a course of treatment.
8. Ganshenkang
1. Factors: Chuanqiong, Astragalus and other natural plant extracts.
2. Efficacy: It has the effects of clearing heat and detoxifying, protecting the liver and kidneys, improving immunity, eliminating water and dissipating stagnation, diuresis and dampness, warming the intestines and constricting the lungs.
3. Dosage: Take orally or drink, 1ml/kg, once a day, for 3-5 days.
Summary of oral medications
Comparison of medication experience for liver disease in dogs and cats
9. Liver complex peptide
This strain is a small molecule polypeptide active substance extracted and purified from the liver of Shenxinqi suckling pigs. It has the following biological effects:
1. It can significantly stimulate the DNA synthesis of mature liver cells, promote the recovery of damaged liver cell mitochondria and rough endoplasmic reticulum, promote the regeneration of liver cells, and accelerate the repair of liver tissue. Restore liver function.
2. Improve the cytosis function of liver Kupffer cells, prevent further damage to liver cells by toxins from the intestinal tract, suppress tumor necrosis factor (TNF) activity, thereby promoting repair after liver necrosis. At the same time, it has the effect of reducing transaminases, serum bilirubin and interrupting thrombin time.
Dosage: 2-3mg/kg.im for dogs and cats, approximately iv.
10. 3AA
Factors: leucine, isoleucine, valine.
These three amino acids are branched chain amino acids, and the side chains in the three molecular structures have branched structures. Mainly metabolized in skeletal muscle.
1. Efficiency:
(1) Valine, leucine, and isoleucine are branched-chain amino acids. When added to the body, they can correct the levels of branched-chain amino acids and The imbalance of rich amino acids prevents liver coma caused by excessive levels of rich amino acids in the brain.
(2) It can promote protein synthesis and increase protein synthesis, benefit the regeneration and repair of liver cells, and can improve hypoalbuminemia.
(3) It is metabolized in muscles, fat, heart, brain and other tissues, generating energy for use by the body and reducing the burden on the liver.
2. Applicable to: Hepatic encephalopathy, severe hepatitis, hepatitis, and chronic exercise hepatitis caused by various reasons. It is more effective before and after hepatobiliary surgery.
Dosage: 10ml/kg/d for dogs and cats.
11. Gardenia yellow
1. Factors: Gardenia, gardenia, astragalus, honeysuckle extract.
Yinchen: can promote bile penetration and the penetration of bile acid and bilirubin in bile.
Gardenia: It has choleretic effect, can promote the penetration of bile, and can suppress the increase of bilirubin in the blood.
Baicalin: It can be used for damp-heat jaundice and has broad-spectrum antibacterial efficiency.
Honeysuckle: has broad-spectrum antibacterial and anti-influenza virus effects
2. It has the effects of clearing heat, detoxifying, and diuresis, and has the effect of reducing jaundice and reducing alanine aminotransferase.
Applicable objects: both dogs and cats. It can be used for acute, delayed, chronic hepatitis and severe hepatitis. It can also be used for the comprehensive treatment of other types of severe hepatitis.
3. Usage: Dilute with 250-500ml of 10% glucose injection and instill.
Section 2 Prescription Food for Liver Disease
1. Royal Liver Prescription Food
Luodai Copper content and reduced zinc content may minimize copper storage in liver cells and intracellular damage caused by cholestasis.
· Controlling sodium intake can reduce portal hypertension and reduce extravascular fluid storage.
· Synergistic antioxidant complex can speed up liver cell degeneration.
·Containing high-energy and highly absorbable plant protein can reduce the burden on the liver, control the occurrence or reversal of liver disease.
Comparison of medication experience for liver disease in dogs and cats
2. Sears (L/D)
Appropriate content of easy-to-digest high-quality protein can help reduce liver function burden and protect liver function.
The added L-carnitine helps protect the normal fat metabolism of the liver.
Adding antioxidants (such as vitamins E and C) can help control cell oxidation and maintain a strong immune system.
Low sodium helps maintain normal blood pressure.
It can be used in cases of hepatitis, biliary liver disease, hepatic encephalopathy and fatty liver.
Taboos: Hyperlipidemia, pregnancy.
Source of the article: Visit Dr. Wang Lili from the Animal Hospital
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